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This¡¡skepticism¡¡soon¡¡spread¡¡to¡¡all¡¡areas¡¡of¡¡his¡¡life¡£¡¡Descartes¡¡doubted¡¡everything¡£¡¡Of¡¡one¡¡thing£»¡¡however£»¡¡
Descartes¡¡had¡¡no¡¡doubt£º¡¡that¡¡he¡¡was¡¡doubting¡£¡¡This¡¡led¡¡to¡¡his¡¡famous¡¡conclusion£»¡¡¡°Cogito£»¡¡ergo¡¡sum¡£¡±¡¡¡°I¡¡
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us¡¡exists¡£¡¡Descartes¡¡also¡¡made¡¡significant¡¡contributions¡¡to¡¡physiology¡£¡¡He¡¡believed¡¡that¡¡what¡¡distinguished¡¡
living¡¡from¡¡nonliving¡¡material¡¡was¡¡¡°animal¡¡spirits¡±¡£¡¡Animal¡¡spirits£»¡¡according¡¡to¡¡Descartes£»¡¡gave¡¡humans¡¡

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their¡¡ability¡¡to¡¡move¡¡and¡¡worked¡¡mechanically£»¡¡like¡¡hydraulics¡£¡¡Although¡¡his¡¡notion¡¡of¡¡animal¡¡spirits¡¡has¡¡
been¡¡shown¡¡incorrect£»¡¡his¡¡study¡¡of¡¡both¡¡animals¡¡and¡¡humans¡¡paved¡¡the¡¡way¡¡for¡¡future¡¡discoveries¡£¡¡
Descartes¡¡also¡¡addressed¡¡the¡¡mind¡ªbody¡¡problem¡£¡¡He¡¡thought¡¡that¡¡there¡¡was¡¡a¡¡physical¡¡body¡¡that¡¡could¡¡be¡¡
studied¡¡scientifically¡¡and¡¡that¡¡there¡¡was¡¡a¡¡mind¡¡that¡¡was¡¡not¡¡physical¡¡and¡¡that¡¡could¡¡not¡¡be¡¡studied¡¡
scientifically¡£¡¡He¡¡felt¡¡that¡¡the¡¡mind¡¡and¡¡body¡¡interacted¡¡in¡¡the¡¡pineal¡¡gland£»¡¡which¡¡sits¡¡at¡¡the¡¡center¡¡of¡¡the¡¡
base¡¡of¡¡the¡¡brain¡£¡¡His¡¡position¡¡was¡¡thus¡¡dualistic¡¡and¡¡interactionist¡£¡¡

Because¡¡of¡¡interference¡¡by¡¡the¡¡Catholic¡¡Church¡¡and¡¡increased¡¡demands¡¡on¡¡his¡¡time¡¡because¡¡of¡¡his¡¡growing¡¡
fame£»¡¡Descartes¡¡moved¡¡to¡¡Sweden¡¡in¡¡1650¡¡to¡¡tutor¡¡Queen¡¡Christina¡£¡¡Unfortunately¡¡for¡¡humanity£»¡¡Queen¡¡
Christina¡¡insisted¡¡on¡¡being¡¡tutored¡¡at¡¡5¡¡A¡£M¡££»¡¡well¡¡before¡¡Descartes¡¯¡¡11¡¡A¡£M¡£¡¡wake¡­up¡¡time¡£¡¡Within¡¡six¡¡
months¡¡of¡¡his¡¡arrival¡¡in¡¡Sweden£»¡¡Descartes¡¡contracted¡¡pneumonia¡¡and¡¡died¡£¡¡

Paul¡¡Broca¡¡£¨1824¡ª1880£©¡¡

Born¡¡in¡¡Sainte¡­Foy¡­la¡­Grand£»¡¡France£»¡¡Broca¡¡was¡¡the¡¡only¡¡son¡¡of¡¡a¡¡physician£»¡¡and¡¡followed¡¡his¡¡father¡¯s¡¡lead£»¡¡
being¡¡professor¡¡of¡¡surgery¡¡and¡¡anthropology¡¡in¡¡Paris¡¡in¡¡1861¡£¡¡During¡¡an¡¡autopsy¡¡on¡¡a¡¡patient¡¡who¡¡had¡¡
suffered¡¡from¡¡severe¡¡speech¡¡deficits£»¡¡Broca¡¡discovered¡¡a¡¡lesion¡¡in¡¡the¡¡left¡¡frontal¡¡lobe¡£¡¡This¡¡discovery¡¡was¡¡the¡¡
first¡¡evidence¡¡supporting¡¡Franz¡¡Gall¡¯s¡¡notion¡¡of¡¡localization¡¡of¡¡brain¡¡function£»¡¡a¡¡concept¡¡that¡¡is¡¡generally¡¡
viewed¡¡as¡¡accurate¡¡by¡¡current¡¡standards¡£¡¡

Broca¡¡was¡¡also¡¡responsible¡¡for¡¡developing¡¡the¡¡early¡¡science¡¡of¡¡craniometry£»¡¡the¡¡measurement¡¡of¡¡the¡¡skull£»¡¡
and¡¡the¡¡anthropological¡¡study¡¡of¡¡the¡¡prehistoric¡¡practice¡¡of¡¡trephining£»¡¡in¡¡which¡¡small¡¡holes¡¡were¡¡made¡¡in¡¡
the¡¡skull¡¡of¡¡presumably¡¡mentally¡¡ill¡¡individuals¡¡in¡¡an¡¡attempt¡¡to¡¡allow¡¡demons¡¡to¡¡escape¡£¡¡He¡¡was¡¡elected¡¡to¡¡
the¡¡French¡¡Senate¡¡in¡¡1879¡¡and¡¡his¡¡radical¡¡political¡¡views¡¡included¡¡the¡¡remendation¡¡that¡¡public¡¡high¡¡
schools¡¡open¡¡their¡¡doors¡¡to¡¡females¡£¡¡

Franz¡¡Gall¡¡£¨1758¡ª1828£©¡¡

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responsible¡¡for¡¡much¡¡of¡¡our¡¡early¡¡understanding¡¡of¡¡the¡¡nervous¡¡system£»¡¡particularly¡¡the¡¡distinction¡¡between¡¡
the¡¡function¡¡of¡¡the¡¡white¡¡£¨myelinated£©¡¡and¡¡gray¡¡£¨nonmyelinated£©¡¡matter¡¡of¡¡the¡¡brain¡£¡¡Along¡¡with¡¡his¡¡student£»¡¡
Johann¡¡Spurzheim£»¡¡Gall¡¡promoted¡¡the¡¡science¡¡of¡¡phrenology£»¡¡in¡¡which¡¡a¡¡person¡¯s¡¡character£»¡¡and¡¡emotional¡¡
and¡¡intellectual¡¡dispositions¡¡could¡¡be¡¡inferred¡¡from¡¡an¡¡assessment¡¡of¡¡the¡¡various¡¡bumps¡¡and¡¡contours¡¡of¡¡the¡¡
head¡£¡¡Although¡¡long¡¡since¡¡discredited¡¡as¡¡legitimate¡¡science£»¡¡phrenology¡¡was¡¡extremely¡¡popular¡¡in¡¡its¡¡day¡£¡¡
£¨Darwin¡¡was¡¡nearly¡¡kept¡¡off¡¡the¡¡HMS¡¡Beagle¡¡because¡¡of¡¡the¡¡shape¡¡of¡¡his¡¡nose¡££©¡¡Nearly¡¡30¡¡phrenological¡¡
societies¡¡were¡¡in¡¡existence¡¡in¡¡England¡¡in¡¡1832£»¡¡and¡¡a¡¡number¡¡of¡¡professional¡¡periodicals¡¡concerning¡¡
phrenology¡¡flourished¡¡curing¡¡the¡¡mid¡­1800s¡£¡¡

Gregor¡¡Mendel¡¡£¨1822¡ª1884£©¡¡

Born¡¡in¡¡Heizendorf£»¡¡Austria£»¡¡Mendel¡¯s¡¡father¡¡was¡¡a¡¡peasant£»¡¡his¡¡mother¡¡a¡¡gardener¡£¡¡After¡¡studying¡¡
philosophy¡¡at¡¡the¡¡University¡¡of¡¡Olmutz£»¡¡Mendel¡¡entered¡¡the¡¡Augustinian¡¡monastery£»¡¡where¡¡many¡¡of¡¡his¡¡
teachers¡¡also¡¡taught¡¡science¡¡and¡¡philosophy¡¡at¡¡the¡¡Gymnasium¡¡or¡¡Philosophical¡¡Institute¡£¡¡Mendel¡¡was¡¡put¡¡
in¡¡charge¡¡of¡¡the¡¡experimental¡¡garden£»¡¡where¡¡he¡¡began¡¡the¡¡studies¡¡that¡¡would¡¡e¡¡to¡¡be¡¡identified¡¡as¡¡the¡¡
founding¡¡of¡¡the¡¡science¡¡of¡¡genetics¡£¡¡Conducting¡¡impressively¡¡systematic¡¡and¡¡thorough¡¡experiments¡¡of¡¡
hybridization¡¡of¡¡peas£»¡¡Mendel¡¡accumulated¡¡evidence¡¡contradicting¡¡the¡¡current¡¡theory¡¡that¡¡inheritance¡¡was¡¡
a¡¡¡°blending¡±¡¡or¡¡bining¡¡process¡£¡¡

Mendel¡¯s¡¡research¡¡was¡¡first¡¡presented¡¡at¡¡a¡¡scientific¡¡meeting¡¡in¡¡1865¡¡and¡¡in¡¡published¡¡form¡¡in¡¡1866£»¡¡but¡¡
went¡¡unnoticed¡£¡¡In¡¡1900£»¡¡however£»¡¡three¡¡separate¡¡scientists¡¡reported¡¡similar¡¡findings£»¡¡despite¡¡having¡¡been¡¡
ignorant¡¡of¡¡Mendel¡¯s¡¡work¡£¡¡

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Roger¡¡Sperry¡¡£¨1913¡ª1994£©¡¡

Sperry¡¡obtained¡¡his¡¡M¡£A¡£¡¡in¡¡psychology¡¡at¡¡Oberlin¡¡College£»¡¡followed¡¡by¡¡a¡¡Ph¡£D¡£¡¡in¡¡zoology¡¡from¡¡the¡¡
University¡¡of¡¡Chicago¡¡in¡¡1941¡£¡¡He¡¡conducted¡¡postdoctoral¡¡research¡¡under¡¡Karl¡¡Lashley¡¡at¡¡Harvard¡¡and¡¡at¡¡
the¡¡Yerkes¡¡Primate¡¡Center¡£¡¡His¡¡early¡¡research¡¡challenged¡¡the¡¡traditional¡¡notion¡¡that¡¡nerves¡¡from¡¡sense¡¡
organs¡¡attach¡¡to¡¡brain¡¡areas¡¡in¡¡nonspecific¡¡ways¡£¡¡Later£»¡¡he¡¡and¡¡his¡¡students¡¡advanced¡¡the¡¡psychological¡¡
study¡¡of¡¡split¡­brain¡¡patients¡¡by¡¡developing¡¡laboratory¡¡tasks¡¡that¡¡allowed¡¡for¡¡precise¡¡assessment¡¡of¡¡the¡¡
frequently¡¡subtle¡¡impairments¡¡experienced¡¡by¡¡recipients¡¡of¡¡the¡¡radical¡¡operation¡£¡¡In¡¡1981£»¡¡he¡¡was¡¡awarded¡¡
the¡¡Nobel¡¡Prize¡¡in¡¡physiology£»¡¡primarily¡¡for¡¡his¡¡pioneering¡¡work¡¡during¡¡the¡¡1960s¡¡on¡¡split¡­brain¡¡
phenomena¡£¡¡Sperry¡¡wrote¡¡later¡¡about¡¡the¡¡mind¡­body¡¡relationship¡¡and¡¡the¡¡ethical¡¡implications¡¡of¡¡modern¡¡
research¡¡on¡¡brain¡¡physiology¡¡and¡¡behavior¡£¡¡

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TIMELINE¡¡

Yea¡¡Event¡¡
r¡¡
1662¡¡Rene¡¡Descartes£»¡¡a¡¡French¡¡philosopher¡ªmathematician£»¡¡published¡¡Trait¡¡de¡¡L¡¯homme£»¡¡introducing¡¡
the¡¡idea¡¡of¡¡reflexive¡¡behavior¡£¡¡
1687¡¡Isaac¡¡Newton¡¡published¡¡Principia¡£¡¡
1739¡¡David¡¡Hume¡¡published¡¡Treatise¡¡on¡¡Human¡¡Nature¡£¡¡
1831¡¡Charles¡¡Darwin¡¡set¡¡sail¡¡on¡¡the¡¡five¡­year¡¡voyage¡¡of¡¡the¡¡HMS¡¡Beagle¡¡
18611865¡¡
The¡¡American¡¡Civil¡¡War¡¡was¡¡fought¡£¡¡
1865¡¡Gergor¡¡Mendel¡¡reported¡¡his¡¡findings¡¡on¡¡genetic¡¡transmission¡¡of¡¡traits¡¡in¡¡garden¡¡peas¡£¡¡
1870¡¡Gustav¡¡Fritsch¡¡and¡¡Eduard¡¡Hitzig¡¡used¡¡electrical¡¡stimulation¡¡to¡¡study¡¡the¡¡cerebral¡¡cortex¡£¡¡
1875¡¡Walther¡¡Flemming£»¡¡Strasburger£»¡¡and¡¡others¡¡discovered¡¡chromosomes¡£¡¡
1884¡¡Oscar¡¡Hertwig¡¡suggested¡¡that¡¡nucleic¡¡acid¡¡was¡¡the¡¡material¡¡responsible¡¡for¡¡the¡¡transmission¡¡of¡¡
hereditary¡¡traits¡£¡¡
19141918¡¡
World¡¡War¡¡I¡¡was¡¡fought¡£¡¡
1929¡¡Karl¡¡Lashley¡¡published¡¡Brain¡¡Mechanisms¡¡and¡¡Intelligence£»¡¡a¡¡monograph¡¡outlining¡¡his¡¡ideas¡¡on¡¡the¡¡
relation¡¡between¡¡the¡¡brain¡¡mechanisms¡¡and¡¡learning¡£¡¡
1933¡¡Ram¨®n¡¡y¡¡Cajal¡¡published¡¡Neuron¡¡Theory¡¡or¡¡Reticular¡¡Theory£¿£º¡¡Objective¡¡Evidence¡¡for¡¡the¡¡Anatomical¡¡
Unity¡¡of¡¡Nerve¡¡Cells£»¡¡arguing¡¡that¡¡the¡¡nervous¡¡system¡¡is¡¡prised¡¡of¡¡neurons¡£¡¡Twenty¡­one¡¡years¡¡
later£»¡¡scientists¡¡using¡¡the¡¡electron¡¡microscope¡¡show¡¡Ram¨®n¡¡y¡¡Cajal¡¯s¡¡arguments¡¡are¡¡correct¡£¡¡
1944¡¡Oswald¡¡Avery£»¡¡Colin¡¡Macleod£»¡¡and¡¡Maelyn¡¡McCarty¡¡discovered¡¡that¡¡DNA¡¡£¨Deoxyribonucleic¡¡
Acid£©¡¡was¡¡the¡¡material¡¡of¡¡which¡¡genes¡¡are¡¡made¡£¡¡
1953¡¡James¡¡Watson¡¡and¡¡Francis¡¡Crick¡¡discovered¡¡the¡¡double¡¡helix¡¡structure¡¡of¡¡DNA¡£¡¡
1957¡¡The¡¡Russian¡¡satellite¡¡Sputnik¡¡was¡¡launched¡£¡¡
1960¨C¡¡
1980¡¡
The¡¡Leakeys£»¡¡Louis¡¡and¡¡Mary£»¡¡and¡¡their¡¡sons¡¡Richard£»¡¡Jonathon£»¡¡and¡¡Philip¡¡discovered¡¡the¡¡
fossilized¡¡remains¡¡of¡¡prehumans¡¡and¡¡the¡¡earliest¡¡humans¡¡near¡¡Lake¡¡Turkana¡¡in¡¡Kenya¡£¡¡
1978¡¡Louise¡¡Brown£»¡¡the¡¡world¡¯s¡¡first¡¡¡°test¡­tube¡¡baby¡±¡¡is¡¡born¡¡in¡¡England¡£¡¡

SUGGESTIONS¡¡FOR¡¡FURTHER¡¡READINGS¡¡

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Carlson£»¡¡N¡£¡¡R¡£¡¡£¨1998£©¡£¡¡Physiology¡¡of¡¡Behavior¡¡£¨6th¡¡ed¡££©¡£¡¡Boston£º¡¡Allyn¡¡and¡¡Bacon¡£¡¡

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